(Val³⁴)-Amyloid β-Protein (1-40)

Description:

Aβ 1-40 and Aβ 1-42 have been used to detect amyloid β-protein multimers in the cerebrospinal fluid of Alzheimer's disease patients. Aβ 1-40 shows both neurotrophic and neurotoxic effects in dependence on the neuronal age and the concentration of the β-protein

Sequence:

DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGVMVGGVV

General

References

Comments (0)

Name	(Val³⁴)-Amyloid β-Protein (1-40)
Category	Beta-Amyloidand Related Peptides
One Letter Code	DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGVMVGGVV
Three Letter Code	{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}{Val}{His}{His}{Gln}{Lys}{Leu}{Val}{Phe}{Phe}{Ala}{Glu}{Asp}{Val}{Gly}{Ser}{Asn}{Lys}{Gly}{Ala}{Ile}{Ile}{Gly}{Val}{Met}{Val}{Gly}{Gly}{Val}{Val}
Molecular Weight	4315.840
Application	Alzheimer's Disease

Fossati, S., et al. "Differential activation of mitochondrial apoptotic pathways by vasculotropic amyloid-β variants in cells composing the cerebral vessel walls." The FASEB Journal 24.1 (2010): 229-241.

Obici, Laura, et al. "A novel AβPP mutation exclusively associated with cerebral amyloid angiopathy." Annals of Neurology: Official Journal of the American Neurological Association and the Child Neurology Society 58.4 (2005): 639-644.