Beta - Amyloid (1 - 28)

Description:

Reports show that synthetic peptides Aß (1-40) and Aß (1-28) have significant effects on normal human plasma cholesterol esterification rate. Both peptides (at concentration of 1 ng/mL) inhibit plasma cholesterol esterification rate by 40-50% compared to the control value.

Sequence:

DAEFRHDSGYEVHHQKLVFFAEDVGSNK

General

References

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Name	Beta - Amyloid (1 - 28)
Category	Beta-Amyloidand Related Peptides
One Letter Code	DAEFRHDSGYEVHHQKLVFFAEDVGSNK
Three Letter Code	{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}{Val}{His}{His}{Gln}{Lys}{Leu}{Val}{Phe}{Phe}{Ala}{Glu}{Asp}{Val}{Gly}{Ser}{Asn}{Lys}
Molecular Weight	3262.500
Application	Alzheimer's Disease

Hanenberg, Michael, et al. "Amyloid-β peptide-specific DARPins as a novel class of potential therapeutics for Alzheimer disease." Journal of Biological Chemistry 289.39 (2014): 27080-27089.

Bailey, Jason A., et al. "Functional activity of the novel Alzheimer's amyloid β-peptide interacting domain (AβID) in the APP and BACE1 promoter sequences and implications in activating apoptotic genes and in amyloidogenesis." Gene 488.1-2 (2011): 13-22.

Alarcón, Juan Marcos, et al. "Ion channel formation by Alzheimer's disease amyloid β-peptide (Aβ40) in unilamellar liposomes is determined by anionic phospholipids." Peptides 27.1 (2006): 95-104.

Zou, Jun, et al. "Catalytic activity of human ADAM33." Journal of Biological Chemistry 279.11 (2004): 9818-9830.

Liu, Ruitian, et al. "Single chain variable fragments against β-amyloid (Aβ) can inhibit Aβ aggregation and prevent Aβ-induced neurotoxicity." Biochemistry 43.22 (2004): 6959-6967.

Sen, Jette W., H. Robert Bergen, and Niels HH Heegaard. "On-Line Immunoaffinity-Liquid Chromatography− Mass Spectrometry for Identification of Amyloid Disease Markers in Biological Fluids." Analytical chemistry 75.5 (2003): 1196-1202.