(Met(O)³⁵)-Amyloid β-Protein (1-40)

Description:

Oxidation of Met35 weakens the formation of Aβ40 oligomers.

Sequence:

DAEFRHDSGYEVHHQKLVFFAEDVGFAMSNKGAIIGLM(O)VGGVV

General

References

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Name	(Met(O)³⁵)-Amyloid β-Protein (1-40)
Category	Beta-Amyloidand Related Peptides
One Letter Code	DAEFRHDSGYEVHHQKLVFFAEDVGFAMSNKGAIIGLM(O)VGGVV
Three Letter Code	{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}{Val}{His}{His}{Gln}{Lys}{Leu}{Val}{Phe}{Phe}{Ala}{Glu}{Asp}{Val}{Gly}{Ser}{Asn}{Lys}{Gly}{Ala}{Ile}{Ile}{Gly}{Leu}{Met(O)}{Val}{Gly}{Gly}{Val}{Val}
Molecular Weight	4345.860
Application	Alzheimer's Disease

Brown, Anne M., et al. "Simulations of monomeric amyloid β-peptide (1–40) with varying solution conditions and oxidation state of Met35: implications for aggregation." Archives of biochemistry and biophysics 545 (2014): 44-52.

Johansson, Ann-Sofi, et al. "Attenuated amyloid-β aggregation and neurotoxicity owing to methionine oxidation." Neuroreport 18.6 (2007): 559-563.

Hou, Liming, et al. "Solution NMR studies of the Aβ (1− 40) and Aβ (1− 42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formation." Journal of the American Chemical Society 126.7 (2004): 1992-2005.

Palmblad, Magnus, Anita Westlind-Danielsson, and Jonas Bergquist. "Oxidation of methionine 35 attenuates formation of amyloid β-peptide 1–40 oligomers." Journal of Biological Chemistry 277.22 (2002): 19506-19510.