[Cys26] - beta - Amyloid (1 - 40), S26C beta - Amyloid (1 - 40)

Description:

S26C beta - Amyloid (1 - 40) has been used for generating the covalently linked Aβ40 homodimer.S26C Aβ40 is perfectly suited for labeling with fluorescent tags

Sequence:

DAEFRHDSGYEVHHQKLVFFAEDVGCNKGAIIGLMVGGVV

General

References

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Name	[Cys26] - beta - Amyloid (1 - 40), S26C beta - Amyloid (1 - 40)
Category	Beta-Amyloidand Related Peptides
One Letter Code	DAEFRHDSGYEVHHQKLVFFAEDVGCNKGAIIGLMVGGVV
Three Letter Code	{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}{Val}{His}{His}{Gln}{Lys}{Leu}{Val}{Phe}{Phe}{Ala}{Glu}{Asp}{Val}{Gly}{Cys}{Asn}{Lys}{Gly}{Ala}{Ile}{Ile}{Gly}{Leu}{Met}{Val}{Gly}{Gly}{Val}{Val}
Molecular Weight	4345.900
Application	Alzheimer's Disease

Jin, Ming, et al. "Soluble amyloid β-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration." Proceedings of the National Academy of Sciences 108.14 (2011): 5819-5824.

O'Nuallain, Brian, et al. "Amyloid β-protein dimers rapidly form stable synaptotoxic protofibrils." Journal of Neuroscience 30.43 (2010): 14411-14419.

Mikhalyov, I., et al. "Designed fluorescent probes reveal interactions between amyloid-β (1–40) peptides and GM1 gangliosides in micelles and lipid vesicles." Biophysical journal 99.5 (2010): 1510-1519.

Shankar, G. M., et al. "Soluble amyloid β-protein dimers isolated directly from Alzheimer disease patients potently impair synaptic plasticity and memory." Nat Med 14 (2008): 837-842.