Beta - Amyloid (1 - 16)

Description:

The Aβ1-14, Aβ1-15, and Aβ1-16 are elevated in cell media and in CSF in response to γ-secretase inhibitor treatment. The fragments can serve as biomarkers in clinical studies of the effect of such inhibitors. There is evidence that Aβ1-14, Aβ1-15, and Aβ1-16 increase dose-dependently in response to γ-secretase inhibitor treatment while Aβ1-42 levels are unchanged.

Sequence:

DAEFRHDSGYEVHHQK

General

References

Comments (0)

Name	Beta - Amyloid (1 - 16)
Category	Beta-Amyloidand Related Peptides
One Letter Code	DAEFRHDSGYEVHHQK
Three Letter Code	{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}{Val}{His}{His}{Gln}{Lys}
Molecular Weight	1955.000
Application	Alzheimer's Disease

Hanenberg, Michael, et al. "Amyloid-β peptide-specific DARPins as a novel class of potential therapeutics for Alzheimer disease." Journal of Biological Chemistry 289.39 (2014): 27080-27089.

Lu, Yu, et al. "Dual-channel electrospray microchip." Journal of The American Society for Mass Spectrometry 24.3 (2013): 454-457.

Gunderson, William A., et al. "Local structure and global patterning of Cu2+ binding in fibrillar amyloid-β [Aβ (1–40)] protein." Journal of the American Chemical Society 134.44 (2012): 18330-18337.

Portelius, Erik, et al. "Evaluation of the performance of novel Aβ isoforms as theragnostic markers in Alzheimer’s disease: from the cell to the patient." Neurodegenerative Diseases 10.1-4 (2012): 138-140.

Portelius, Erik, et al. "Novel AβIsoforms in Alzheimer's Disease-Their Role in Diagnosis and Treatment." Current pharmaceutical design 17.25 (2011): 2594-2602.

Mustafa, M. K., et al. "Detection of β-amyloid peptide (1–16) and amyloid precursor protein (APP770) using spectroscopic ellipsometry and QCM techniques: A step forward towards Alzheimers disease diagnostics." Biosensors and Bioelectronics 26.4 (2010): 1332-1336.