Beta - Amyloid (2 - 42)

Description:

Beta - Amyloid (2 - 42) promotes phagocytosis by macrophages.It is a biomarker that distinguishes alzheimer's disease from other degenerative dementias, such as frontotemporal dementias (FTD). for differentiating AD from other degenerative dementias, such as frontotemporal dementias (FTD).

Sequence:

AEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

General

References

Comments (0)

Name	Beta - Amyloid (2 - 42)
Category	Beta-Amyloidand Related Peptides
One Letter Code	AEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Three Letter Code	{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}{Val}{His}{His}{Gln}{Lys}{Leu}{Val}{Phe}{Phe}{Ala}{Glu}{Asp}{Val}{Gly}{Ser}{Asn}{Lys}{Gly}{Ala}{Ile}{Ile}{Gly}{Leu}{Met}{Val}{Gly}{Gly}{Val}{Val}{Ile}{Ala}
Molecular Weight	4399.000
Application	Alzheimer's Disease

Wiltfang, Jens, et al. "Elevation of β-amyloid peptide 2–42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells." Journal of Biological Chemistry 276.46 (2001): 42645-42657.

Condic, Mateja, et al. "N-truncation and pyroglutaminylation enhances the opsonizing capacity of Aβ-peptides and facilitates phagocytosis by macrophages and microglia." Brain, behavior, and immunity 41 (2014): 116-125.

Bibl, Mirko, et al. "Aminoterminally truncated and oxidized amyloid-β peptides in the cerebrospinal fluid of Alzheimer's disease patients." Journal of Alzheimer's Disease 29.4 (2012): 809-816.

Bibl, Mirko, et al. "Cerebrospinal fluid amyloid-β 2-42 is decreased in Alzheimer’s, but not in frontotemporal dementia." Journal of neural transmission 119.7 (2012): 805-813.