Mast Cell Degranulating (MCD) Peptide

Description:

The highly basic MCD peptide is present in the venom of the European honeybee, Apis mellifera. At low doses, it causes mast cell degranulation and subsequent histamine release. At higher doses, it produces an anti-inflammatory effect, which may be beneficial in rheumatic and allergic diseases.

Sequence:

IKCNCKRHVIKPHICRKICGKN-NH₂ (Disulfide bridge: 3 - 15, 5 - 19)

General

References

Comments (0)

Name	Mast Cell Degranulating (MCD) Peptide
Category	Toxins
One Letter Code	IKCNCKRHVIKPHICRKICGKN-NH₂ (Disulfide bridge: 3 - 15, 5 - 19)
Three Letter Code	{Ile}{Lys}{Cys}{Asn}{Cys}{Lys}{Arg}{His}{Val}{Ile}{Lys}{Pro}{His}{Ile}{Cys}{Arg}{Lys}{Ile}{Cys}{Gly}{Lys}{Asn}-NH₂ (Disulfide bridge: 3-15, 5-19) (Disulfide bridge: 3 - 15, 5 - 19)
Molecular Weight	2587.250
Application	Inflammation Research

R.Bessone et al.,Neurochem. Int.,45,1039(2004)

H.Vacher et al.,FEBS Lett.,501,31(2001)