[Pyr11] - beta - Amyloid (11 - 42)

Description:

Aβs are generated by the proteolytic processing of the amyloid β-precursor protein (APP). Subsequent cleavage by g-secretase gives rise to Aβ (1-40/42) and Aβ (11-40/42). Aβ (11-40) and Aβ (11-42) are major Aβ cleavage products generated by BACE.

Sequence:

{pGLU}VHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

General

References

Comments (0)

Name	[Pyr11] - beta - Amyloid (11 - 42)
Category	Beta-Amyloidand Related Peptides
One Letter Code	{pGLU}VHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Three Letter Code	{pGLU}{Val}{His}{His}{Gln}{Lys}{Leu}{Val}{Phe}{Phe}{Ala}{Glu}{Asp}{Val}{Gly}{Ser}{Asn}{Lys}{Gly}{Ala}{Ile}{Ile}{Gly}{Leu}{Met}{Val}{Gly}{Gly}{Val}{Val}{Ile}{Ala}
Molecular Weight	3317.900
Application	Alzheimer's Disease

Liu, Kangning, Robert W. Doms, and Virginia M-Y. Lee. "Glu11 site cleavage and N-terminally truncated Aβ production upon BACE overexpression." Biochemistry 41.9 (2002): 3128-3136.