PUMA BH3

Description:

PUMA binds Bcl-2 inducing cytochrome C release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.

Sequence:

EEQWAREIGAQLRRMADDLNAQYER

General

References

Comments (0)

Name	PUMA BH3
Category	Apoptosis Peptides
One Letter Code	EEQWAREIGAQLRRMADDLNAQYER
Three Letter Code	{Glu}{Glu}{Gln}{Trp}{Ala}{Arg}{Glu}{Ile}{Gly}{Ala}{Gln}{Leu}{Arg}{Arg}{Met}{Ala}{Asp}{Asp}{Leu}{Asn}{Ala}{Gln}{Tyr}{Glu}{Arg}
Molecular Weight	3049.300
Application

Chipuk, Jerry E., et al. "PUMA couples the nuclear and cytoplasmic proapoptotic function of p53." Science 309.5741 (2005): 1732-1735.

Nakano, Katsunori, and Karen H. Vousden. "PUMA, a novel proapoptotic gene, is induced by p53." Molecular cell 7.3 (2001): 683-694.

Yu, Jian, et al. "PUMA induces the rapid apoptosis of colorectal cancer cells." Molecular cell 7.3 (2001): 673-682.

Han, Jia-wen, et al. "Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals." Proceedings of the National Academy of Sciences 98.20 (2001): 11318-11323.