Apelin-12 (human, bovine, mouse, rat)

Description:

Apelin-12, one of the most potent apelin peptides, is an endogenous ligand of the human orphan receptor APJ. It lowers blood pressure via a nitric oxide-dependent mechanism.

Sequence:

RPRLSHKGPMPF

General

References

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Name	Apelin-12 (human, bovine, mouse, rat)
Category	Apelin Peptides
One Letter Code	RPRLSHKGPMPF
Three Letter Code	{Arg}{Pro}{Arg}{Leu}{Ser}{His}{Lys}{Gly}{Pro}{Met}{Pro}{Phe}
Molecular Weight	1422.700
Application	Cardiovascular System & DiseasesNitric Oxide Research

O'Shea, Marie, et al. "Inhibitory effect of apelin-12 on nocturnal food intake in the rat." Nutritional neuroscience 6.3 (2003): 163-167.

Lee, Dennis K., et al. "Modification of the terminal residue of apelin-13 antagonizes its hypotensive action." Endocrinology 146.1 (2005): 231-236.

Wang, Guiyun, et al. "Apelin, a new enteric peptide: localization in the gastrointestinal tract, ontogeny, and stimulation of gastric cell proliferation and of cholecystokinin secretion." Endocrinology 145.3 (2004): 1342-1348.

Busch, Raila, et al. "Regulation of the endothelial apelin/APJ system by hemodynamic fluid flow." Cellular signalling 27.7 (2015): 1286-1296.

Cheng, Xing, Xiao Shuo Cheng, and Catherine CY Pang. "Venous dilator effect of apelin, an endogenous peptide ligand for the orphan APJ receptor, in conscious rats." European journal of pharmacology 470.3 (2003): 171-175.