Enfuvirtide

Description:

Enfuvirtide is a 36 amino acid peptide with the N-terminus acetylated. It belongs to the therapeutic class of fusion inhibitors by binding to gp41 and impeding the conformational changes in gp41 necessary for fusion of the virus with the cell.

Sequence:

Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH₂

General

References

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Name	Enfuvirtide
Category	Antiviral Peptides
One Letter Code	Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH₂
Three Letter Code	Ac-{Tyr}{Thr}{Ser}{Leu}{Ile}{His}{Ser}{Leu}{Ile}{Glu}{Glu}{Ser}{Gln}{Asn}{Gln}{Gln}{Glu}{Lys}{Asn}{Glu}{Gln}{Glu}{Leu}{Leu}{Glu}{Leu}{Asp}{Lys}{Trp}{Ala}{Ser}{Leu}{Trp}{Asn}{Trp}{Phe}-NH₂
Molecular Weight	4491.940
Application	Antimicrobial & Antiviral PeptidesInfectious DiseaseVirology

Streinu-Cercel, Adrian, et al. "Switching from a toxicity-causing antiretroviral to enfuvirtide in patients with HIV: the SWITCH TOX study." HIV clinical trials 9.6 (2008): 375-386.

Ruof, Jörg, et al. "Cost-efficacy comparison among three antiretroviral regimens in HIV-1 infected, treatment-experienced patients." Clinical drug investigation 27.7 (2007): 469-479.

Manfredi, Roberto, and Sergio Sabbatani. "A novel antiretroviral class (fusion inhibitors) in the management of HIV infection. Present features and future perspectives of enfuvirtide (T-20)." Current medicinal chemistry 13.20 (2006): 2369-2384.

Fung, Horatio B., and Yi Guo. "Enfuvirtide: a fusion inhibitor for the treatment of HIV infection." Clinical therapeutics 26.3 (2004): 352-378.