(D-Ala¹)-Peptide T amide

Description:

This peptide inhibits the entry of the virus.

Sequence:

{D-Ala}STTTNYT-NH₂

General

References

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Name	(D-Ala¹)-Peptide T amide
Category	Antiviral Peptides
One Letter Code	{D-Ala}STTTNYT-NH₂
Three Letter Code	{D-Ala}{Ser}{Thr}{Thr}{Thr}{Asn}{Tyr}{Thr}-NH₂
Molecular Weight	856.890
Application	Infectious DiseaseVirology

Pollicita, Michela, et al. "Profound anti-HIV-1 activity of DAPTA in monocytes/macrophages and inhibition of CCR5-mediated apoptosis in neuronal cells." Antiviral Chemistry and Chemotherapy 18.5 (2007): 285-295.

Polianova, Maria T., et al. "Chemokine receptor-5 (CCR5) is a receptor for the HIV entry inhibitor peptide T (DAPTA)." Antiviral research 67.2 (2005): 83-92.

Rosi, Susanna, et al. "Neuroinflammation alters the hippocampal pattern of behaviorally induced Arc expression." Journal of Neuroscience 25.3 (2005): 723-731.

Herwald, Heiko, et al. "M protein, a classical bacterial virulence determinant, forms complexes with fibrinogen that induce vascular leakage." Cell 116.3 (2004): 367-379.

Ruff, M. R., et al. "Update on D-ala-peptide T-amide (DAPTA): a viral entry inhibitor that blocks CCR5 chemokine receptors." Current HIV research 1.1 (2003): 51-67.

Polianova, Maria T., et al. "Antiviral and immunological benefits in HIV patients receiving intranasal peptide T (DAPTA)." Peptides 24.7 (2003): 1093-1098.