Tachyplesin I

Description:

Tachyplesin I inhibits the growth of both Gramnegative and -positive bacteria and forms a complex with bacterial lipopolysaccharides. Furthermore this peptide has been shown to have antiviral activity against vesicular stomatitis virus, influenza A virus and HIV-1.

Sequence:

KWCFRVCYRGICYRRCR-NH₂ (Disulfide bridge: 3 - 16, 7 - 12)

General

References

Comments (0)

Name	Tachyplesin I
Category	Antimicrobial and Related Peptides
One Letter Code	KWCFRVCYRGICYRRCR-NH₂ (Disulfide bridge: 3 - 16, 7 - 12)
Three Letter Code	{Lys}{Trp}{Cys}{Phe}{Arg}{Val}{Cys}{Tyr}{Arg}{Gly}{Ile}{Cys}{Tyr}{Arg}{Arg}{Cys}{Arg}-NH₂ (Disulfide bridge: 3-16, 7-12) (Disulfide bridge: 3 - 16, 7 - 12)
Molecular Weight	2263.780
Application	Antimicrobial & Antiviral Peptides

Ramamoorthy, Ayyalusamy, et al. "Deletion of all cysteines in tachyplesin I abolishes hemolytic activity and retains antimicrobial activity and lipopolysaccharide selective binding." Biochemistry 45.20 (2006): 6529-6540.

Buck, Christopher B., et al. "Carrageenan is a potent inhibitor of papillomavirus infection." PLoS pathogens 2.7 (2006).

Laederach, Alain, Amy H. Andreotti, and D. Bruce Fulton. "Solution and micelle-bound structures of tachyplesin I and its active aromatic linear derivatives." Biochemistry 41.41 (2002): 12359-12368.