Research Area
Eynav Klechevsky obtained her PhD from the Technion – Israel inst. of technology in collaboration with the Baylor Institute for Immunology Research in Dallas Texas investigating antigen presentation by tumor and dendritic cells, and functional specializations of unique dendritic cell subsets. My work continue to investigate molecular regulators controlling these cell and their ability to drive adaptive processes and in maintaining immune homeostasis. Our work aims to harnessing such mechanisms in the design of novel immunotherapies against cancer and autoinflammatory diseases.
Team Description
Dendritic cells are a group of cells with a unique capacity to sense and respond to the environment and induce adaptive and long-term memory immunity against specific antigens. We’ve been studying basic principals by which human dendritic cells subsets exert their function, with the ultimate goal of harnessing our understanding of the innate immune system to develop novel therapies against cancer and inflammatory diseases. Our laboratory has also made pioneering discoveries in the identifications of novel dendritic cell types, and have been working to identify the dendritic cell-derived factors that contribute to the activation of T cells and other immune cells.
Team Members
Team Show
Publications
1.He M, Roussak K, Ma F, Borcherding N, Garin V, White M, Schutt C, Jensen TI, Zhao Y, Iberg CA, Shah K, Bhatia H, Korenfeld D, Dinkel S, Gray J, Ulezko Antonova A, Ferris S, Donermeyer D, Lindestam Arlehamn C, Gubin MM, Luo J, Gorvel L, Pellegrini M, Sette A, Tung T, Bak R, Modlin RL, Fields RC, Schreiber RD, Allen PM, Klechevsky E. CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses. Science. 2023 Feb 17;379(6633):eabg2752. doi: 10.1126/science.abg2752. Epub 2023 Feb 17. PMID: 36795805.
2.Do TH, Ma F, Andrade PR, Teles R, de Andrade Silva BJ, Hu C, Espinoza A, Hsu JE, Cho CS, Kim M, Xi J, Xing X, Plazyo O, Tsoi LC, Cheng C, Kim J, Bryson BD, O'Neill AM, Colonna M, Gudjonsson JE, Klechevsky E, Lee JH, Gallo RL, Bloom BR, Pellegrini M, Modlin RL. TREM2 macrophages induced by human lipids drive inflammation in acne lesions. Sci Immunol. 2022 Jul 22;7(73):eabo2787. doi: 10.1126/sciimmunol.abo2787. Epub 2022 Jul 22. PMID: 35867799; PMCID: PMC9400695.
3.Ma F, Hughes TK, Teles RMB, Andrade PR, de Andrade Silva BJ, Plazyo O, Tsoi LC, Do T, Wadsworth MH 2nd, Oulee A, Ochoa MT, Sarno EN, Iruela-Arispe ML, Klechevsky E, Bryson B, Shalek AK, Bloom BR, Gudjonsson JE, Pellegrini M, Modlin RL. The cellular architecture of the antimicrobial response network in human leprosy granulomas. Nat Immunol. 2021 Jul;22(7):839-850. doi: 10.1038/s41590-021-00956-8. Epub 2021 Jun 24. PMID: 34168371; PMCID: PMC8579511.
4.Oulee A, Ma F, Teles RMB, de Andrade Silva BJ, Pellegrini M, Klechevsky E, Harman AN, Rhodes JW, Modlin RL. Identification of Genes Encoding Antimicrobial Proteins in Langerhans Cells. Front Immunol. 2021 Aug 26;12:695373. doi: 10.3389/fimmu.2021.695373. PMID: 34512625; PMCID: PMC8426439.
5.Balin SJ, Pellegrini M, Klechevsky E, Won ST, Weiss DI, Choi AW, Hakimian J, Lu J, Ochoa MT, Bloom BR, Lanier LL, Stenger S, Modlin RL. Human antimicrobial cytotoxic T lymphocytes, defined by NK receptors and antimicrobial proteins, kill intracellular bacteria. Sci Immunol. 2018 Aug 31;3(26):eaat7668. doi: 10.1126/sciimmunol.aat7668. PMID: 30171080; PMCID: PMC6431239.
6.Korenfeld D, Roussak K, Dinkel S, Vogel TP, Pollack H, Levy J, Leiding JW, Milner J, Cooper M, Klechevsky E. STAT3 Gain-of-Function Mutations Underlie Deficiency in Human Nonclassical CD16+ Monocytes and CD141+ Dendritic Cells. J Immunol. 2021 Nov 15;207(10):2423-2432. doi: 10.4049/jimmunol.2000841. Epub 2021 Oct 15. PMID: 34654687; PMCID: PMC8578438.
7.Balin SJ, Pellegrini M, Klechevsky E, Won ST, Weiss DI, Choi AW, Hakimian J, Lu J, Ochoa MT, Bloom BR, Lanier LL, Stenger S, Modlin RL. Human antimicrobial cytotoxic T lymphocytes, defined by NK receptors and antimicrobial proteins, kill intracellular bacteria. Sci Immunol. 2018 Aug 31;3(26):eaat7668. doi: 10.1126/sciimmunol.aat7668. PMID: 30171080; PMCID: PMC6431239.
8.Ma F., Hughes T., Teles R., Andrade P., Silva B., Plazyo O., Tsoi L., Do T., Wadsworth M., Oulee A., Ochoa M., Sarno E., Iruela-Arispe ML., Klechevsky E., Bryson B., Shalek A., Bloom B., Gudjonsson J., Pellegrini M. Single Cell and Spatial Transcriptomics Defines the Cellular Architecture of the Antimicrobial Response Network in Human Leprosy Granulomas Nat. Immunol. Nat Immunol. 2021 Jul;22(7):839-850. Epub 2021 Jun 24. Doi: 10.1038/s41590-021-00956-8.
9.Korenfeld, D., Gorvel, L., Munk, A., Man, J., Schaffer, A., Tung, T., Mann, C., Klechevsky, E. A type of human skin dendritic cell marked by CD5 is associated with the development of inflammatory skin disease. (2017) JCI Insight. Sep 21;2(18). PMCID: PMC5621884 • DOI: 10.1172/jci.insight.96101.
10.Gorvel, L., Korenfeld, D., Tung, T., Klechevsky, E. (2017) Dendritic Cell-Derived IL-32α: A Novel Inhibitory Cytokine of NK Cell Function. J Immunol. 199(4):1290-1300. PMCID: PMC5544929 • DOI: 10.4049/jimmunol.1601477.
11.Artyomov, M.N., Munk, A., Gorvel, L., Korenfeld, D., Cella, M., Tung, T., Klechevsky, E. (2015) Modular expression analysis reveals functional conservation between human Langerhans Cells and mouse cross-priming dendritic cells. J Exp Med. May 4;212(5):743-57. PMCID PMC4419344 • DOI: 10.1084/jem.20131675.
12.Klechevsky, E. (2015) Functional diversity of human Dendritic Cells (Springer Adv Exp Med Biol. 2015;850:43-54.) DOI: 10.1007/978-3-319-15774-0_4.
13.Banchereau, J., Zurawski, S., Thompson-Snipes, L., Blanck, J.P., Clayton, S., Munk, A., Cao, Y., Wang, Z., Khandelwal, S., Hu, J., McCoy, W.H. 4th, Palucka, K.A., Reiter, Y., Fremont, D.H., Zurawski, G., Colonna, M., Shaw, A.S., 9.Klechevsky, E. (2012) Immunoglobulin-like transcript receptors on human dermal CD14+ dendritic cells act as a CD8-antagonist to control cytotoxic T cell priming. Proc Natl Acad Sci USA. Nov 13;109(46):18885-90. PMCID PMC3503187 • DOI: 10.1073/pnas.1205785109.
14.Banchereau, J., Thompson-Snipes, L., Zurawski, S., Blanck, J.P., Cao, Y., Clayton, S., Gorvel, J.P., Zurawski, G., Klechevsky, E. (2012) The differential production of cytokines by human Langerhans Cells and dermal CD14+ DCs controls CTL priming. Blood. Jun; 14;119(24):5742-9. PMCID PMC3382933 • DOI: 10.1182/blood-2011-08-371245.
15.Klechevsky, E., Morita, R., Liu, M., Cao, Y., Coquery, S., Thompson-Snipes, L., Briere, F., Chaussabel, D., Zurawski, G., Palucka, A.K., Reiter, Y., Banchereau, J. and Ueno, H. (2008) Functional specializations of human epidermal Langerhans Cells and CD14+ dermal dendritic cells. Immunity. Sep; 29(3):497-510. PMCID2688399 DOI: 10.1016/j.immuni.2008.07.013.