We are 14 undergrads with backgrounds in biochem, cell & molecular biology, biology, bioengineering, computer engineering, sustainability studies, finance, behavioral neurobiology, and fine arts. Our iGEM predecessors won silver, bronze, & gold medals. This year, we are developing a space-compatible biomanufacturing microorganism to advance outer space exploration. Our project begins with the creation of an open source database / web application compiling microgravity-induced changes in gene expression in S. Cerevisiae and other model organisms. The database is a selection guide for the design of our microgravity-induced stress reporter strains. Candidate reporter strains will be tested and characterized in simulated microgravity conditions. Selected reporter strains will serve as a control for the design of S. cerevisiae strains that are resistant to microgravity-induced stress. Our resistant strains will have the potential for diverse applications in space including the continuous biomanufacturing of biofuels, drugs, fresh foods, and biomaterials.