More than 35 years have passed since the first reported cases of AIDS and the discovery of HIV, and despite tremendous efforts no vaccine has been developed that could effectively protect against HIV infection in the vast majority of people. Similarly, there is no treatment available that could actually cure an ongoing HIV infection. Potent anti-retroviral drugs extend the life expectancy of HIV-infected individuals considerably, but these drugs are not curative. The only evident cure has been demonstrated in just a single HIV patient, Timothy Ray Brown, known as the "Berlin patient". AAV-mediated delivery of potent anti-HIV broadly neutralizing antibodies circumvents the need of a vaccine-induced immune response, and represents a promising immunization alternative for the prevention and treatment of HIV infection.